Sabrina Shameen Alam, MS

Graduate student 

Department of Human Genetics

McGill University

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Sabrina Shameen Alam is one of the earliest members of EuGEF lab since its inception. She has completed her BSc and MS degrees from the department of Genetic Engineering & Biotechnology, University of Chittagong and achieved the accolade “Prime Minister Gold Medal” for her extraordinary academic performance. In EuGEF lab, she was involved in a breast cancer research project where the pattern of Sonic Hedgehog expression was investigated in triple negative breast cancer patients. Currently, she is doing her PhD with the prestigious Queen Elizabeth II Diamond Jubilee scholarship in the department of Human Genetics, McGill University, Canada. In her project funded by Canadian Institutes of Health Research, she is trying to understand how splicing defects causes craniofacial abnormalities in a human syndrome, by using a mouse model that she has successfully generated through CRISPR-Cas9 technique. 

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Ms. Alam has achieved many competitive fellowships and awards including Helmsley Trust Fellowship at Cold Spring Harbor Laboratory (USA), McGill University Faculty of Medicine Student Award, award from FRQS, Graduate Excellence Award, etc. She has also won several awards as best presenter at conferences arranged by several organizations including Canadian Society of Developmental Biology.

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Sabrina is a cheerful mother of three and she enjoys her free time doing fun activities with her children

 

Selected Publications:

        

• Beauchamp MC, Alam SS, Kumar S, Jerome-Majewska LA. Spliceosomopathies and neurocristopathies: two sides of the same coin? Dev Dyn. 2020. doi: 10.1002/dvdy.183. Review. PMID: 32315467

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• Keser V, Lachance JB, Alam SS, Lim Y, Scarlata E, Kaur A, Zhang TF, Lv S, Lachapelle P, O'Flaherty C, Golden JA, Jerome-Majewska LA. Snap29 mutant mice recapitulate neurological and ophthalmological abnormalities associated with 22q11 and CEDNIK syndrome.  Commun Biol.  2019 Oct11; 2:375. doi: 10.1038/s42003-019-0601-5.PMID:    31633066

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• Gurumurth CB, O'Brien AR, Quadros RM,..Alam SS…Liaw L, Miano JM, Burgio G. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2. PMID: 31446895       

                   

• Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK, Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S, Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer. Sci Rep. 2017 May 11;7(1):1796. doi: 10.1038/s41598-017-01268-4. PMID: 28496132

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• Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh". Sci Rep. 2016 Jan 5;6: 18830. doi: 10.1038/srep18830. PMID: 26727947