Md Wahiduzzaman, PhD
Laboratory In-charge,
Bangladesh Medical Research Council &
Deputy Project Director,
Establishment of Bangamata National Cellular and Molecular
Research Center (BNCMRC), BMRC Bhaban, Mohakhali, Dhaka-1212
Md. Wahiduzzaman completed his PhD degree from the Aichi Medical University School of Medicine, Japan. Earlier, he received his B.Sc (Honors) and MS (Thesis) degree from the Dept. of Biochemistry & Molecular Biology, University of Chittagong, Bangladesh. After completing B.Sc. degree, he started his research career as a part of MS degree in the 'Laboratory of Eukaryotic Gene Expression & Function' (EuGEF) of the Dept. of Biochemistry and Molecular Biology, University of Chittagong. After obtaining the MS degree, he joined as a Research Associate in the same lab. At the end of 2014, he went to Japan and joined in the Dept. of Biochemistry, Aichi Medical University School of Medicine as a Foreign Researcher. From April 2015, he continued his research as a PhD student in the same lab. On March 2, 2019, he received his PhD degree from Aichi Medical University School of Medicine, Japan.
He has a significant contribution to different areas of research in medical science and has been highly recognized by several high impact journals including Nucleic Acids Research, Cell Reports, Cancer Letters, Cancer Science, Journal of cell science, Scientific Reports, Oncology Reports, Cancer Medicine etc.
His research focused on AAV mediated gene targeting (Nucleic Acids Res, 2016), and the development of an alternative and combinatorial therapeutic approach for the chronic myelogenous leukemia (CML) (Cancer Letters, 2018). He assessed the efficacy of a novel combinatorial arsenic trioxide (ATO) and cisplatin (CDDP) treatment in human Bcr-Abl positive (Ph+) leukemic cells. Besides, he worked to find out the potential biomarker for early diagnosis of different subtypes of malignant pleural mesothelioma (MPM) and its therapeutic improvement. He established NF2 knock out normal mesothelial and MPM cell lines and studied the molecular mechanism behind mutant NF2 driven tumorigenesis in MPM (Cancer Science, 2018).
Currently he is working as a Deputy Project Director, Establishment of Bangamata National Cellular and Molecular Research Center (BNCMRC) with a view to establish a world class research center in the field of Cellular and Molecular Biology with special focus to medical science.
Dr. Wahiduzzaman has received many awards in recognition of his significant research contributions including National Science and Technology (NST) fellowship (2012-2013) for pursuing MS thesis, Research & Development (R&D) grant from NST (2013-2014), foreign researcher grants (2014) from Aichi Medical University, Japan, Aikeika scholarship (2015) supporting PhD studentship in Japan, Nittoku foundation scholarship (2018) supporting PhD studentship in Japan.
Selected Publications:
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Karnan S, Ota A, Murakami H, Rahman ML, Hasan MN, Wahiduzzaman M, Hanamura I, Quang Vu L, Inoko A, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y. Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma. Cell Death Discov. 2020 Nov 18;6(1):127. doi:10.1038/s41420-020-00364-1. PMID: 33298865.
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Ota A, Hanamura I, Karnan S, Inaguma S, Takei N, Lam VQ, Mizuno S, Kanasugi J, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Ikeda H, Takami A, Hosokawa Y. Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells. J Interferon Cytokine Res. 2020 Aug;40(8):389-405. doi: 10.1089/jir.2020.0111. Epub 2020 Jul 23. PMID: 32721246; PMCID: PMC7462034.
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Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A. Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Cancer Sci. 2020 May;111(5):1663-1675. doi: 10.1111/cas.14386. Epub 2020 Apr 9. PMID: 32176823; PMCID: PMC7226186.
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Kondo S, Ota A, Ono T, Karnan S, Wahiduzzaman M, Hyodo T, Lutfur Rahman M, Ito K, Furuhashi A, Hayashi T, Konishi H, Tsuzuki S, Hosokawa Y, Kazaoka Y. Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma. Cancer Med. 2020 Apr;9(8):2904-2917. doi: 10.1002/cam4.2931. Epub 2020 Feb 25. PMID: 32096304; PMCID: PMC7163100.
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Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H. Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53. Cell Rep. 2020 Jan 28;30(4):1195-1207.e7. doi: 10.1016/j.celrep.2019.12.064. PMID: 31995758.
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Wahiduzzaman M, Karnan S, Ota A, Hanamura I, Murakami H, Inoko A, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y. Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma. Cancer Sci. 2019 Jan;110(1):180-193. doi: 10.1111/cas.13871. Epub 2018 Dec 14. PMID: 30417500; PMCID: PMC6317947.
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Wahiduzzaman M, Ota A, Karnan S, Hanamura I, Mizuno S, Kanasugi J, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Takami A, Hosokawa Y. Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo. Cancer Lett. 2018 Oct 1;433:117-130. doi:10.1016/j.canlet.2018.06.027. Epub 2018 Jun 23. PMID: 29944906.
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Ota A, Nakao H, Sawada Y, Karnan S, Wahiduzzaman M, Inoue T, Kobayashi Y, Yamamoto T, Ishii N, Ohashi T, Nakade Y, Sato K, Itoh K, Konishi H, Hosokawa Y, Yoneda M. Δ40p53α suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells. J Cell Sci. 2017 Feb 1;130(3):614-625. doi: 10.1242/jcs.190736. Epub 2016 Dec 15. PMID: 27980070; PMCID: PMC5312733.
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Ito K, Ota A, Ono T, Nakaoka T, Wahiduzzaman M, Karnan S, Konishi H, Furuhashi A, Hayashi T, Yamada Y, Hosokawa Y, Kazaoka Y. Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines. Oncol Rep. 2016 Nov;36(5):2991-2998. doi:10.3892/or.2016.5068. Epub 2016 Sep 5. PMID: 27600098.
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Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh. Sci Rep. 2016 Jan 5;6:18830. doi: 10.1038/srep18830. PMID: 26727947; PMCID: PMC4700415.
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Noman AS, Dilruba S, Mohanto NC, Rahman L, Khatun Z, Riad W, Al Mamun A, Alam S, Aktar S, Chowdhury S, Saud ZA, Rahman Z, Hossain K, Haque A. Arsenic-induced Histological Alterations in Various Organs of Mice. J Cytol Histol. 2015 May;6(3):323. doi: 10.4172/2157-7099.1000323. Epub 2015 Apr 24. PMID: 26740907; PMCID: PMC4698904.
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