M JUNAYED NAYEEM, MS

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PhD Candidate 

Department of Physiology, Graduate School of Medicine 

Aichi Medical University 

Nagakute, Aichi, Japan. 

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Junayed received his BSc and MS from the University of Chittagong in Bangladesh. In his MS level Research, he worked at EuGEF Lab under the supervision of Professor Abu Shadat M Noman to know the role of numerous signaling pathways (e.g. Shh, BRCA1/2) on breast oncogenesis. For his PhD, Junayed moved to Aichi Medical University, Japan where he worked with Professor Motohiko Sato, studying the role of tyrosine kinase receptors in prostate cancer. Currently he is also studying the G-protein mediated regulation of tyrosine kinase receptors in prostate cancer. In the separate project, he works with Dr Aya Yamamura to know the roles of Calcium Censing Receptor (CaSR, a G-protein coupled receptor) on Pulmonary Arterial Hypertension (PAH). 

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In his free time, Junayed enjoys listening music and watching movies. 

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Selected Publications: 

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• Yamamura A, Nayeem MJ, Sato M. The Rho kinase 2 (ROCK2)-specific inhibitor KD025  ameliorates the development of pulmonary arterial hypertension. Biochem Biophys Res  Commun. 2020 Nov 5:S0006-291X(20)32035-0. doi: 10.1016/j.bbrc.2020.10.106. Epub  ahead of print. PMID: 33160621. 

 

• Mamun AA, Hayashi H, Yamamura A, Nayeem MJ, Sato M. Hypoxia induces the  translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells.  J Physiol Sci. 2020 Sep 22;70(1):44. doi: 10.1186/s12576-020-00773-y. PMID: 32962633.

 

• Yamamura A, Nayeem MJ, Al Mamun A, Takahashi R, Hayashi H, Sato M. Platelet derived growth factor up-regulates Ca2+-sensing receptors in idiopathic pulmonary arterial  hypertension. FASEB J. 2019 Jun;33(6):7363-7374. doi: 10.1096/fj.201802620R. Epub  2019 Mar 13. PMID: 30865840. 

 

• A Yamamura, MJ Nayeem, M Sato. Calcilytics inhibit the proliferation and migration of  human prostate cancer PC-3 cells. Journal of pharmacological sciences Volume 139, Issue  3, March 2019, Pages 254-257. 

 

• Noman ASM, Parag RR, Rashid MI, Islam S, Rahman MZ, Chowdhury AA, Sultana A,  Jerin C, Siddiqua A, Rahman L, Nayeem MJ, Akther S, Baidya S, Shil RK, Rahman M,  Shirin A, Mahmud R, Hossain SMI, Sumi SA, Chowdhury A, Basher SB, Hasan A, Bithy  S, Aklima J, Chowdhury N, Hasan MN, Banu T, Chowdhury S, Hossain MM, Yeger H,  Farhat WA, Islam SS. Chemotherapeutic resistance of head and neck squamous cell  carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2- antioxidant pathway activation. Cell Death Dis. 2020 Aug 20;11(8):663. doi:  10.1038/s41419-020-02907-x. PMID: 32814771; PMCID: PMC7438524. 

 

• Noman ASM, Parag RR, Rashid MI, Rahman MZ, Chowdhury AA, Sultana A, Jerin C,  Siddiqua A, Rahman L, Shirin A, Nayeem MJ, Mahmud R, Akther S, Shil RK, Hossain I,  Alam S, Chowdhury A, Basher SB, Hasan A, Bithy S, Aklima J, Rahman M, Chowdhury  N, Banu T, Karakas B, Yeger H, Farhat WA, Islam SS. Widespread expression of Sonic  hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected  tumors and are potential therapeutic targets for HPV-negative head and neck cancer. Ther  Adv Med Oncol. 2020 Mar 13;12:1758835920911229. doi: 10.1177/1758835920911229.  PMID: 32206093; PMCID: PMC7074584. 

 

• Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK,  Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud  MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S,  Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A,  Yeger H, Farhat WA, Islam SS. Serum sonic hedgehog (SHH) and interleukin-(IL-6) as  dual prognostic biomarkers in progressive metastatic breast cancer. Sci Rep. 2017 May 11;7(1):1796. doi: 10.1038/s41598-017-01268-4. PMID: 28496132; PMCID:  PMC5431756. 

 

• Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M,  Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H,  Farhat WA, Islam SS. Overexpression of sonic hedgehog in the triple negative breast  cancer: clinicopathological characteristics of high burden breast cancer patients from  Bangladesh. Sci Rep. 2016 Jan 5;6:18830. doi: 10.1038/srep18830. PMID: 26727947;  PMCID: PMC4700415.