M Lutfur Rahman, MS

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Ph.D. Student, Dept. of Biochemistry

Aichi Medical University, Nagakute-Aichi-Japan.

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Mr. Md. Lutfur Rahman holds B.Sc. and MS degrees in Biochemistry and Molecular Biology from the University of Chittagong, Bangladesh. He is presently pursuing his Ph.D. on improving the efficiency of targeted knock-in mediated by CRISPR/Cas9 nickases under the supervision of Professor Dr. Hiroyuki Konishi in the dept. of Biochemistry, Aichi Medical University, Japan. He is also involved with some other sub-projects to reveal molecular target therapies for malignant pleural mesothelioma patients.

  

Since he started his research career at the Laboratory of Eukaryotic Gene Expression and Function (EuGEF), BMB, CU, in January 2013, his indomitable willpower for research has been continued and published several research articles as a co-author in the renowned scientific journals. He accomplished his MS thesis from the EuGEF laboratory on arsenic mediated alteration of heat shock proteins (HSPs) under the supervision of Professor Dr. Abu Shadat M Noman, BMB, CU. At EuGEF, he is connected with cutting-edge research on understanding the mechanism of signaling molecules in cancer progression to identify novel diagnostic, prognostic, and therapeutic approaches for breast cancer and head & neck cancer patients. 

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On vacation, he usually prefers to go to natural sights with family members or friends. 

 

 

Selected Publications:​

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• Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H. Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53. Cell Rep. 2020 Jan 28;30(4):1195-1207.e7. doi: 10.1016/j.celrep.2019.12.064. PMID: 31995758.

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• Karnan S, Ota A, Hideki M, Rahman ML, Hasan MN, Wahiduzzaman M, Hanamura I, Lam VQ, Inoko A, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y. Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma. Cell Death Discov. 6, 127 (2020). https://doi.org/10.1038/s41420-020-00364-1.

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• Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A. Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Cancer Sci. 2020 May;111(5):1663-1675. doi: 10.1111/cas.14386. Epub 2020 Apr 9. PMID: 32176823; PMCID: PMC7226186.

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• Kondo S, Ota A, Ono T, Karnan S, Wahiduzzaman M, Hyodo T, Rahman ML, Ito K, Furuhashi A, Hayashi T, Konishi H, Tsuzuki S, Hosokawa Y, Kazaoka Y. Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma. Cancer Med. 2020 Apr;9(8):2904-2917. doi: 10.1002/cam4.2931. Epub 2020 Feb 25. PMID: 32096304; PMCID: PMC7163100.

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• Ota A, Hanamura I, Karnan S, Inaguma S, Takei N, Lam VQ, Mizuno S, Kanasugi J, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Ikeda H, Takami A, Hosokawa Y. Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells. J Interferon Cytokine Res. 2020 Aug;40(8):389-405. doi: 10.1089/jir.2020.0111. Epub 2020 Jul 23. PMID: 32721246; PMCID: PMC7462034.

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• Noman ASM, Parag RR, Rashid MI, Rahman MZ, Chowdhury AA, Sultana A, Jerin C, Siddiqua A, Rahman ML, Shirin A, Nayeem J, Mahmud R, Akther S, Shil RK, Hossain I, Alam S, Chowdhury A, Basher SB, Hasan A, Bithy S, Aklima J, Rahman M, Chowdhury N, Banu T, Karakas B, Yeger H, Farhat WA, Islam SS. Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer. Ther Adv Med Oncol. 2020 Mar 13; 12:1758835920911229. doi: 10.1177/1758835920911229. PMID: 32206093; PMCID: PMC7074584.

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• Noman ASM, Parag RR, Rashid MI, Islam S, Rahman MZ, Chowdhury AA, Sultana A, Jerin C, Siddiqua A, Rahman ML, Nayeem J, Akther S, Baidya S, Shil RK, Rahman M, Shirin A, Mahmud R, Hossain SMI, Sumi SA, Chowdhury A, Basher SB, Hasan A, Bithy S, Aklima J, Chowdhury N, Hasan MN, Banu T, Chowdhury S, Hossain MM, Yeger H, Farhat WA, Islam SS. Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation. Cell Death Dis. 2020 Aug 20;11(8):663. doi: 10.1038/s41419-020-02907-x. PMID: 32814771; PMCID: PMC7438524.

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• Wahiduzzaman M, Karnan S, Ota A, Hanamura I, Murakami H, Inoko A, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y. Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma. Cancer Sci. 2019 Jan;110(1):180-193. doi: 10.1111/cas.13871. Epub 2018 Dec 14. PMID: 30417500; PMCID: PMC6317947.

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• Wahiduzzaman M, Ota A, Karnan S, Hanamura I, Mizuno S, Kanasugi J, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Takami A, Hosokawa Y. Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo. Cancer Lett. 2018 Oct 1;433:117-130. doi: 10.1016/j.canlet.2018.06.027. Epub 2018 Jun 23. PMID: 29944906.

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• Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh. Sci Rep. 2016 Jan 5;6:18830. doi: 10.1038/srep18830. PMID: 26727947; PMCID: PMC4700415.

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• Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK, Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S, Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer. Sci Rep. 2017 May 11;7(1):1796. doi: 10.1038/s41598-017-01268-4. PMID: 28496132; PMCID: PMC5431756.

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• Noman AS, Dilruba S, Mohanto NC, Rahman ML, Khatun Z, Riad W, Al Mamun A, Alam S, Aktar S, Chowdhury S, Saud ZA, Rahman Z, Hossain K, Haque A. Arsenic-induced Histological Alterations in Various Organs of Mice. J Cytol Histol. 2015 May;6(3):323. doi: 10.4172/2157-7099.1000323. Epub 2015 Apr 24. PMID: 26740907; PMCID: PMC4698904.