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Eukaryotic Gene Expression & Function (EuGEF) Research Group

Abu Shadat Mohammod Noman,PhD

Visiting Professor,Department of Pathology

McGill University

Professor, Department of Biochemistry & Molecular Biology,University of Chittagong

Founder and Principal Investigator

EuGEF Research Group

Publication:

Islam, Syed Shahidul and Noman, Abu Shadat M., Transmission Dynamics and Contact Tracing Assessment of COVID-19 in Chattogram, Bangladesh and Potential Risk of Close Contacts at Different Exposure Settings. Available at SSRN: https://ssrn.com/abstract=3677863 or http://dx.doi.org/10.2139/ssrn.3677863

Ali MY, Oliva CR, Noman ASM, Allen BG, Goswami PC, Zakharia Y, Monga V, Spitz DR, Buatti JM, Griguer CE. Radioresistance in Glioblastoma and the Development of Radiosensitizers. Cancers (Basel). 2020 Sep 3;12(9):2511. doi: 10.3390/cancers12092511. PMID: 32899427; PMCID: PMC7564557.

Noman ASM, Parag RR, Rashid MI, Islam S, Rahman MZ, Chowdhury AA, Sultana A, Jerin C, Siddiqua A, Rahman L, Nayeem J, Akther S, Baidya S, Shil RK, Rahman M, Shirin A, Mahmud R, Hossain SMI, Sumi SA, Chowdhury A, Basher SB, Hasan A, Bithy S, Aklima J, Chowdhury N, Hasan MN, Banu T, Chowdhury S, Hossain MM, Yeger H, Farhat WA, Islam SS. Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation. Cell Death Dis. 2020 Aug 20;11(8):663. doi: 10.1038/s41419-020-02907-x. PMID: 32814771; PMCID: PMC7438524.

Noman ASM, Parag RR, Rashid MI, Rahman MZ, Chowdhury AA, Sultana A, Jerin C, Siddiqua A, Rahman L, Shirin A, Nayeem J, Mahmud R, Akther S, Shil RK, Hossain I, Alam S, Chowdhury A, Basher SB, Hasan A, Bithy S, Aklima J, Rahman M, Chowdhury N, Banu T, Karakas B, Yeger H, Farhat WA, Islam SS. Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer. Ther Adv Med Oncol. 2020 Mar 13;12:1758835920911229. doi: 10.1177/1758835920911229. PMID: 32206093; PMCID: PMC7074584.

Gloria Assaker, Anne Camirand, Bassam Abdulkarim, Atilla Omeroglu, Jean Deschenes, Kurian Joseph, Abu Shadat Mohammod Noman, Agnihotram V Ramana Kumar, Richard Kremer, Siham Sabri, PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease, JNCI Cancer Spectrum, Volume 4, Issue 1, February 2020, pkz063, https://doi.org/10.1093/jncics/pkz063

Assaker G, Camirand A, Abdulkarim B, Omeroglu A, Deschenes J, Joseph K, Noman ASM, Ramana Kumar AV, Kremer R, Sabri S. PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease. JNCI Cancer Spectr. 2019 Aug 29;4(1):pkz063. doi: 10.1093/jncics/pkz063. PMID: 32296756; PMCID: PMC7050156.

Islam SS, Uddin M, Noman ASM, Akter H, Dity NJ, Basiruzzman M, Uddin F, Ahsan J, Annoor S, Alaiya AA, Al-Alwan M, Yeger H, Farhat WA. Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1. EBioMedicine. 2019 May;43:211-224. doi: 10.1016/j.ebiom.2019.04.061. Epub 2019 May 10. PMID: 31085100; PMCID: PMC6558306

Abu Shadat Mohammod Noman, Bassam Abdulkarim, Siham Sabri. Identification of novel potential biomarkers of response to sunitinib in glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4699.

Noman, Abu Shadat M and Parag, Rashed R and Rashid, Irfanur and Rahman, Zillur and Chowdhury, Ali Asgar and Sultana, Afrin and Jerin, ChandSultana and Siddiqua, Ayesha and Rahman, Lutfur and Shirin, Afsana and Nayeem, Junayed and Mahmud, Reaz and Akther, Sonam and Shil, Rajib and Hossain, Ikram and Alam, Sharmin and Chowdhury, Afrina and Basher, Shabnam and Hasan, Abul and Bithy, Shammy and Aklima, Jannatul and Rahman, Mizanur and Banu, Tahmina and Karakas, Bedri and Yeger, Herman and Farhat, Walid and Islam, Syed S., Sonic Hedgehog (SHH) Status Determines the Chemotherapeutic Outcomes in High Risk Stage II and III Head and Neck Cancer Patients (July 17, 2018). Available at SSRN: https://ssrn.com/abstract=3216194 or http://dx.doi.org/10.2139/ssrn.3216194

Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK, Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S, Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer. Sci Rep. 2017 May 11;7(1):1796. doi: 10.1038/s41598-017-01268-4. PMID: 28496132; PMCID: PMC5431756.Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK, Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S, Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer. Sci Rep. 2017 May 11;7(1):1796. doi: 10.1038/s41598-017-01268-4. PMID: 28496132; PMCID: PMC5431756.

Islam SS, Mokhtari RB, Noman AS, Uddin M, Rahman MZ, Azadi MA, Zlotta A, van der Kwast T, Yeger H, Farhat WA. Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer. Mol Carcinog. 2016 May;55(5):537-51. doi: 10.1002/mc.22300. Epub 2015 Mar 1. PMID: 25728352.

Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh. Sci Rep. 2016 Jan 5;6:18830. doi: 10.1038/srep18830. PMID: 26727947; PMCID: PMC4700415.

Noman AS, Dilruba S, Mohanto NC, Rahman L, Khatun Z, Riad W, Al Mamun A, Alam S, Aktar S, Chowdhury S, Saud ZA, Rahman Z, Hossain K, Haque A. Arsenic-induced Histological Alterations in Various Organs of Mice. J Cytol Histol. 2015 May;6(3):323. doi: 10.4172/2157-7099.1000323. Epub 2015 Apr 24. PMID: 26740907; PMCID: PMC4698904.

Tumurkhuu G, Koide N, Dagvadorj J, Noman AS, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Oda M, Nagahama M, Sakurai J, Yokochi T. The inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-induced intracellular ceramide generation. Int J Med Microbiol. 2009 Dec;299(8):554-62. doi: 10.1016/j.ijmm.2009.04.003. Epub 2009 May 20. Erratum in: Int J Med Microbiol. 2015 May;305(3):433. Iftekar-E-Khuda, Imtiaz [corrected to Iftakhar-E-Khuda, Imtiaz]. PMID: 19467928.

Koide N, Naiki Y, Morikawa A, Tumurkhuu G, Dagvadorj J, Noman AS, Iftekar-E-Khuda I, Komatsu T, Yoshida T, Yokochi T. Nystatin-induced nitric oxide production in mouse macrophage-like cell line RAW264.7. Microbiol Immunol. 2009 May;53(5):295-300. doi: 10.1111/j.1348-0421.2009.00118.x. Epub 2009 Feb 4. PMID: 19457171.

Rahman M, Al Mamun A, Karim MR, Islam K, Al Amin H, Hossain S, Hossain MI, Saud ZA, Noman AS, Miyataka H, Himeno S, Hossain K. Associations of total arsenic in drinking water, hair and nails with serum vascular endothelial growth factor in arsenic-endemic individuals in Bangladesh. Chemosphere. 2015 Feb;120:336-42. doi: 10.1016/j.chemosphere.2014.08.003. Epub 2014 Aug 31. PMID: 25180936.

Wu S, Dole K, Hong F, Noman AS, Issacs J, Liu B, Li Z. Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors. J Biol Chem. 2012 Jun 8;287(24):19896-903. doi: 10.1074/jbc.M112.343848. Epub 2012 Apr 24. PMID: 22532561; PMCID: PMC3370174.

Haque A, Noman AS, Koide N, Odkhuu E, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T. An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Cancer Immunol Immunother. 2011 Oct;60(10):1439-46. doi: 10.1007/s00262-011-1048-9. Epub 2011 Jun 5. PMID: 21644032.

Haque A, Koide N, Iftakhar-E-Khuda I, Noman AS, Odkhuu E, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway. Microbiol Immunol. 2011 Mar;55(3):160-7. doi: 10.1111/j.1348-0421.2010.00304.x. PMID: 21204955.

Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011 Feb;17(1):97-105. doi: 10.1177/1753425909353641. Epub 2009 Dec 18. PMID: 20023007.

Haque A, Koide N, Iftakhar-E-Khuda I, Noman AS, Odkhuu E, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway. Microbiol Immunol. 2011 Mar;55(3):160-7. doi: 10.1111/j.1348-0421.2010.00304.x. PMID: 21204955.

Dagvadorj J, Tumurkhuu G, Naiki Y, Noman AS, Iftakhar-E-Khuda I, Badamtseren B, Komatsu T, Koide N, Yoshida T, Yokochi T. Endotoxin-induced lung injury in α-galactosylceramide-sensitized mice is caused by failure of interleukin-4 production in lung natural killer T cells. Clin Exp Immunol. 2010 Oct;162(1):169-77. doi: 10.1111/j.1365-2249.2010.04225.x. Epub 2010 Aug 19. PMID: 20659123; PMCID: PMC2990943.

Khuda II, Koide N, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. Immunology. 2010 Sep;131(1):59-66. doi: 10.1111/j.1365-2567.2010.03274.x. Epub 2010 Apr 6. PMID: 20406300; PMCID: PMC2966758.

Shadat NM, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1 (RIZ1) regulates the proliferation of monocytic leukemia cells via activation of p53. Cancer Invest. 2010 Oct;28(8):806-12. doi: 10.3109/07357907.2010.494323. PMID: 20594067

Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression. Immunol Lett. 2010 Jul 8;131(2):166-9. doi: 10.1016/j.imlet.2010.04.006. Epub 2010 Apr 24. PMID: 20417662..

Dagvadorj J, Naiki Y, Tumurkhuu G, Noman AS, Iftakhar-E-Khuda I, Komatsu T, Koide N, Yoshida T, Takashi Yokochi. Tumor necrosis factor-a augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation. Immunology. 2010 Jan;129(1):97-104. doi: 10.1111/j.1365-2567.2009.03154.x. PMID: 20050332; PMCID: PMC2807490.

Abstract A61: Retinoblastoma protein‐interacting zinc finger 1 (RIZ1) regulates proliferation of monocytic leukemia cells in response to tumor necrosis factor (TNF)‐α via activation of p53 Abu Shadat M. Noman, Naoki Koide, ImtiazI.E. Khuda, Jargalsaikhan Dagvadorj, Gantsetseg Tumurkhuu, Yoshikazu Naiki, Takayuki Komatsu, Tomoaki Yoshida and Takashi Yokochi .DOI: 10.1158/0008-5472.FBCR09-A61

Tumurkhuu G, Koide N, Dagvadorj J, Noman AS, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Oda M, Nagahama M, Sakurai J, Yokochi T. The inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-induced intracellular ceramide generation. Int J Med Microbiol. 2009 Dec;299(8):554-62. doi: 10.1016/j.ijmm.2009.04.003. Epub 2009 May 20. Erratum in: Int J Med Microbiol. 2015 May;305(3):433. Iftekar-E-Khuda, Imtiaz [corrected to Iftakhar-E-Khuda, Imtiaz]. PMID: 19467928.

Khuda II, Koide N, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology. 2009 Sep;128(1 Suppl):e700-6. doi: 10.1111/j.1365-2567.2009.03063.x. Epub 2009 Feb 9. PMID: 19740331; PMCID: PMC2753960.

Dagvadorj, J., Naiki, Y., Tumurkhuu, G., Shadat, A., Iftekar-E-Khuda, I., Koide, N., Komatsu, T., Yoshida, T., & Yokochi, T. (2009). Interleukin (IL)-10 attenuates lipopolysaccharide-induced IL-6 production via inhibition of IκB-ζ activity by Bcl-3. Innate Immunity, 15(4), 217–224. https://doi.org/10.1177/1753425909103738

Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Thalidomide inhibits lipopolysaccharide-induced nitric oxide production and prevents lipopolysaccharide-mediated lethality in mice. FEMS Immunol Med Microbiol. 2009 Aug;56(3):204-11. doi: 10.1111/j.1574-695X.2009.00567.x. Epub 2009 May 6. PMID: 19538513.

Koide N, Naiki Y, Morikawa A, Tumurkhuu G, Dagvadorj J, Noman AS, Iftekar-E-Khuda I, Komatsu T, Yoshida T, Yokochi T. Nystatin-induced nitric oxide production in mouse macrophage-like cell line RAW264.7. Microbiol Immunol. 2009 May;53(5):295-300. doi: 10.1111/j.1348-0421.2009.00118.x. Epub 2009 Feb 4. PMID: 19457171.

Iftakhar-E-Khuda I, Koide N, Hassan F, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Novel mechanism of U18666A-induced tumour necrosis factor-alpha production in RAW 264.7 macrophage cells. Clin Exp Immunol. 2009 Mar;155(3):552-8. doi: 10.1111/j.1365-2249.2008.03779.x. PMID: 19220841; PMCID: PMC2669532.

Noman AS, Koide N, Hassan F, I-E-Khuda I, Dagvadorj J, Tumurkhuu G, Islam S, Naiki Y, Yoshida T, Yokochi T. Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production via down-regulation of MyD88 expression. Innate Immun. 2009 Feb;15(1):33-41. doi: 10.1177/1753425908099317. PMID: 19201823.

Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation. Biochem Biophys Res Commun. 2008 Oct 3;374(4):683-7. doi: 10.1016/j.bbrc.2008.07.090. Epub 2008 Jul 26. PMID: 18662673.

Islam MR, Islam SM, Noman AS, Khanam JA, Ali SM, Alam S, Lee MW. Biological Screening of a Novel Nickel (II) Tyrosine Complex. Mycobiology. 2007 Mar;35(1):25-9. doi: 10.4489/MYCO.2007.35.1.025. Epub 2007 Mar 31. PMID: 24015064; PMCID: PMC3763082.

A.S.M. Noman, M.A. Hoque, M.M. Haque, F. Pervin, M.R. Karim,Nutritional and anti-nutritional components in Pachyrhizus erosus L. tuber,Food Chemistry, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2006.06.055.

A.S.M. Noman, M.A. Hoque, P.K. Sen, M.R. Karim,Purification and some properties of α-amylase from post-harvest Pachyrhizus erosus L. tuber,Food Chemistry,ISSN 0308-8146,https://doi.org/10.1016/j.foodchem.2005.07.056.

A.S.M. Noman, M.A. Hoque, P.K. Sen, M.R. Karim,Purification and some properties of α-amylase from post-harvest Pachyrhizus erosus L. tuber,December 2006,Food Chemistry 99(3):444-449 ,DOI: 10.1016/j.foodchem.2005.07.05

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